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Wittig Reagents

The Wittig reaction was discovered in 1954 by Georg Wittig [for which he was later awarded the Nobel Prize in Chemistry] and involves the use of organophosphorus ylides to produce substituted alkenes. A major advantage of this technique is that the location of the double bond is fixed and a whole range of Wittig reagents [phosphonium or phosphorane compounds] has been developed to capitalise on this.
 
Simple Wittig Reagents are very reactive and unstable in the presence of moisture and air. They are usually prepared fresh in a dry solvent under nitrogen or argon and used immediately. However there are many which are stable enough to be sold commercially, although some have only been developed at R&D scale.
 
Because of its reliability and applicability, the Wittig reaction has become a standard tool for organic chemists in the synthesis of pharmaceuticals, agrochemicals, functional chemicals and their intermediates.
 
From both its global sourcing expertise, and its partner’s production and custom synthesis capabilities, Gee Lawson is able to offer these materials across the spectrum of scale and application. Some examples of the materials available are listed below, but we welcome enquiries for any Wittig reagent from research through to production scale. Please look at our full range of synthetic reagents and ask us for any related item.